{"id":4833,"date":"2023-09-13T09:46:48","date_gmt":"2023-09-13T02:46:48","guid":{"rendered":"http:\/\/localhost\/chem\/?p=4833"},"modified":"2026-03-02T14:04:44","modified_gmt":"2026-03-02T07:04:44","slug":"dr-chanakan-tongsook","status":"publish","type":"post","link":"https:\/\/chem.sc.su.ac.th\/?p=4833&lang=en","title":{"rendered":"Dr. Chanakan Tongsook"},"content":{"rendered":"
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Email: <\/span>tongsook.c@gmail.com, tongsook_c@su.ac.th<\/h4>\n

Room: <\/span>223 Science Building 3<\/h4>\n

Tel.: <\/span> 034-109686 ext. 207313<\/h4>\n

Website:<\/span>-<\/h4>\n

Education:<\/span><\/h3>\n

Ph.D. (Biochemistry) Graz University of Technology, Austria <\/h4>\n

M.Sc. (Biochemistry) Mahidol University, Thailand <\/h4>\n

B.Sc. (Chemistry) Silpakorn University, Thailand <\/h4>\n<\/div>\n<\/div><\/div><\/div><\/div>
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Research Interest:<\/span><\/strong><\/h3>\n

Mechanistic and molecular enzymology, enzyme kinetics, biocatalytic synthesis, and protein biochemistry<\/h4>\n

Publications:<\/span><\/strong><\/h3>\n
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    Tongsook, C.<\/span>,<\/strong> Boonkumkrong, R., Thepthit, Y. (2022). \u201cEnhancement of recombinant N,N-8-amino-8-demethyl-D-riboflavin dimethyltransferase (RosA) protein expression in E. coli for production of antibiotics and flavin-derivatives.\u201d Pure and Applied Chemistry International Conference 2022 Proceeding, \u00a0June30 -July 1,2022. 715-721. King Mongkut's Institute of Technology Ladkrabang, Bangkok.<\/h4>\n<\/li>\n
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    Pitsawong, W., Chenprakhon, P., Dhammaraj, T., Medhanavyn, D., Sucharitakul, J. and Tongsook, C.<\/span>,<\/strong> van Berkel, WJH., Chaiyen, P., and Miller, AF. (2020). \u201cTuning of pKa values activates substrates in flavin-dependent aromatic hydroxylases.\u201d J Biol Chem.<\/strong><\/span>, 295(12): 3965-3981. (SCOPUS impact factor 4.238 in 2019)<\/h4>\n<\/li>\n
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    Chenprakhon, P., P. Pimviriyakul, Tongsook<\/strong>,<\/span> , <\/strong>Chaiyen, P. (2020). Phenolic hydroxylases. The Enzymes, Elsevier. 47: 283-326.<\/h4>\n<\/li>\n
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    Pornsuwan, S., Maenpuen, S., Kamutira, P., Watthaisong, P., Thotsaporn, K., Tongsook, C.<\/strong><\/span>, Juttulapa, M., Nijvipakul, S., Chaiyen, P. (2017). \u201c3,4-Dihydroxyphenylacetate 2,3-dioxygenase from Pseudomonas aeruginosa: An Fe(II)-containing enzyme with fast turnover.\u201d PLoS One,<\/strong><\/span> 12(2): e0171135.<\/h4>\n<\/li>\n
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    Tongsook, C.<\/span>,<\/strong> Niederhauser, J., Kronegger, E., Straganz, G., Macheroux, P. (2017). \u201cLeucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.\u201d Biochimica et Biophysica Acta,<\/strong><\/span> 1863(1): 188-199.<\/h4>\n<\/li>\n
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    Dhammaraj, T., Pinthong, C., Visitsatthawong, S., Tongsook, C.<\/span>,<\/strong> Surawatanawong, P., Chaiyen, P. (2016). \u201cA single-site mutation at Ser146 expands the reactivity of the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase.\u201d ACS Chemical Biology,<\/strong><\/span> 11(10): 2889-2896.<\/h4>\n<\/li>\n
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    Tongsook, C.<\/span>,<\/strong> Uhl, MK., Jankowitsch, F., Mack, M., Gruber, K., Macheroux, P. (2016). \u201cStructural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.\u201d FEBS J,<\/strong><\/span> 283: 1531-1549.<\/h4>\n<\/li>\n
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    Heidari, A., Tongsook, C.<\/strong><\/span>, Najafipour, R., Musante, L., Vasli, N., Garshasbi, M., Hu, H., Mittal, K., McNaughton, AJ., Sritharan, K., Hudson, M., Stehr, H., Talebi, S., Moradi, M., Darvish, H., Arshad Rafiq, M., Mozhdehipanah, H., Rashidinejad, A., Samiei, S., Ghadami, M., Windpassinger, C., Gillessen-Kaesbach, G., Tzschach, A., Ahmed, I., Mikhailov, A., Stavropoulos, DJ., Carter, MT., Keshavarz, S., Ayub, M., Najmabadi, H., Liu, X., Ropers, HH., Macheroux, P., Vincent, JB. (2015). \u201cMutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.\u201d Hum Mol Genet,<\/strong><\/span> 24: 5697-5710.<\/h4>\n<\/li>\n
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    Bernkopf, M., Webersinke, G., Tongsook, C<\/strong>.<\/span>, Koyani, CN., Rafiq, MA., Ayaz, M., M\u00fcller, D., Enzinger, C., Aslam, M., Naeem, F., Schmidt, K., Gruber, K., Speicher, MR., Malle, E., Macheroux, P., Ayub, M., Vincent, JB., Windpassinger, C., Duba, HC. (2014). \u201cDisruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.\u201d Hum Mol Genet,<\/strong><\/span>: 4015-4023.<\/h4>\n<\/li>\n
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    Sucharitakul, J., Tongsook, C<\/strong>.<\/span>, Pakotiprapha, D., van Berkel WJ, Chaiyen, P. (2013). \u201cThe reaction kinetics of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1 provide an understanding of the para-hydroxylation enzyme catalytic cycle.\u201d J Biol Chem,<\/strong><\/span> 288: 35210-35221.<\/h4>\n<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

    Email: tongsook.c@gmail.com, tongsook_c@su.ac.th Room: 223 Science Building 3 Tel.: 034-109686 ext. 207313 Website:- Education: Ph.D. (Biochemistry) Graz University of Technology, Austria M.Sc. (Biochemistry) Mahidol University, Thailand B.Sc. (Chemistry) Silpakorn University, Thailand Research Interest: Mechanistic and molecular enzymology, enzyme kinetics, biocatalytic synthesis, and protein biochemistry Publications: Tongsook, C., Boonkumkrong, R., Thepthit, Y. (2022). \u201cEnhancement of recombinant […]<\/p>\n","protected":false},"author":11,"featured_media":6855,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96],"tags":[],"class_list":["post-4833","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biochemistry"],"_links":{"self":[{"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/posts\/4833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4833"}],"version-history":[{"count":7,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/posts\/4833\/revisions"}],"predecessor-version":[{"id":6875,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/posts\/4833\/revisions\/6875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=\/wp\/v2\/media\/6855"}],"wp:attachment":[{"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chem.sc.su.ac.th\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}