Asst. Prof. Dr. Panupun Limpachayaporn


Room: 1145 Science Building 1

Tel.: 034-147008

Fax: 034-147002



Dr. rer. nat. (Chemistry) University of Münster, Germany

Diplom (Chemie) University of Göttingen, Germany

B.Sc. (Chemistry) Silpakorn University, Thailand

Research Interest::

  • Synthesis and Cytotoxicity towards Various Cancer Cell Lines of Sorafenib Analogues
  • Development of Heterocylic Fragments as Anti-Cancer and Anti-Microbial Agents
  • Structural Modifications of Bioactive Natural Products for Improvement of Biological Activities


  • Singpanna, K., Limpachayaporn, P., Sukma, M., Athipornchai, A., Nuntharatanapong, N. (2022). “Synthesis of Fluorinated N- Benzylaniline Derivatives and Evaluations on Anti-Tyrosinase and Anti-Melanogenic Activities.” Key Engineering Materials, 914: 87-92.

  • Oekchuae, S., Sirirak, J., Charoensuksai, P., Wongprayoon, P., Chuaypen, N., Boonsombat, J., Ruchirawat, S., Tangkijvanich, P., Suksamrarn, A., Limpachayaporn, P. (2022). “The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2.” Pharmaceuticals, 15: 504. (Scopus)

  • Wongprayoon, P., Leelasart, S., Jantham, J., Pootaeng-on, Y., Oekchuae, S., Limpachayaporn, P., Rayanil, K., Charoensuksai, P. (2022). “A triterpenoid friedelan-3ß-ol isolated from Euphorbia lactea exhibited cytotoxic activity against HN22 cells by inducing an S-phase cell cycle arrest.” Journal of Applied Pharmaceutical Science, 12(10): 031-048.

  • Pengnam, S., Wongprayoon, P., Limpachayaporn, P., Rayanil, K., Charoensuksai, P. (2022). “Synergistic activity of friedelan-3β-ol isolated from Euphorbia lactea and doxorubicin against MDA-MB-231 breast cancer cell line.” Science, Engineering and Health Studies, 16: 22050011.

  • Limpachayaporn, P., Nuchpun, S., Sirirak, J., Charoensuksai, P., Wongprayoon, P., Chuaypen, N., Tangkijvanich, P., Suksamrarn, A. (2022) “meta-Ureidophenoxy-1,2,3-triazole hybrid as a novel scaffold for promising HepG2 hepatocellular carcinoma inhibitors: Synthesis, biological evaluation and molecular docking studies.” Bioorganic & Medicinal Chemistry, 74, 117048. (ISI)

  • Singpanna, K., Dechsri, K., Patrojanasophon, P., Limpachayaporn, P., Opanasopit, P., Nuntharatanapong, N. (2021). “Transdermal delivery, cytotoxicity and anti-melanogenic activity of p-chlorophenyl benzyl ether loaded-liposomes.” Journal of Drug Delivery Science and Technology, 65: 102746. (Scopus)

  • Palakhachane, S., Ketkaew, Y., Chuaypen, N., Sirirak, J., Boonsombat, J., Ruchirawat, S., Tangkijvanich, P., Suksamrarn, A., Limpachayaporn, P. (2021). “Synthesis of sorafenib analogues incorporating a 1, 2, 3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines.” Bioorganic Chemistry, 112: 104831. (Scopus)

  • Matako, Y., Suttisingtong, K., Boonsombat, J., Sirirak, J., Limpachayaporn, P. (2021). “The Synthetic Pathways of a New 1,2,3-Triazole-Containing Sorafenib Analogue and Its Cytotoxicity towards Cancer Cell Lines.” Rajamangala University of Technology Srivijaya Research Journal, 13(1): 244-258. (TCI 1)

  • Singpanna, K., Nuntharatanapong, N., Rojanarata, T., Limpachayaporn, P., Patrojanasophon, P., Opanasopit, P. (2021). “Development and evaluation of p-chlorophenyl benzyl ether-loaded microemulsions for transdermal delivery.” Journal of Current Science and Technology, 11(1): 90-99. (Scopus)

  • Singpanna, K., Oekchuae, S., Jareonkunmetee, K., Athipornchai, A., Nuntharatanapong, N., Opanasopit, P., Limpachayaporn, P. (2020). “SYNTHESIS AND ANTI-TYROSINASE ACTIVITY EVALUATION OF FLUORINATED CHALCONE AND PHENYL BENZYL ETHER DERIVATIVES.” Thai Bull Pharm Sci, 15(1): 81-89.

  • Riam- Amatakun, W. , Limpachayaporn, P., Pizon, J. R. L. , Opanasopit, P., Nuntharatanapon, N. (August 2019). “Anti-melanogenic activity of p-chlorophenyl benzyl ether in α-msh-induced mouse melanoma b16f10 cells.” Proceedings of International Conference and Exhibition on Pharmaceutical Sciences and Technology (PST 2019), Key Engineering Materials, 819, 118-123. June 18-19, 2019. Bangkok, Thailand.

  • Palakhachane, S., Ketkaew, Y., Chuaypen, N., Tangkijvanich, P., Suksamrarn, A., Limpachayaporn, P. (2019). “The preliminary studies on the synthesis and the cytotoxicity towards HepG2 and Huh7 of a new series of sorafenib analogues: Replacement of aryl urea with a triazole ring.” in Proceedings of the 45th Congress on Science and Technology of Thailand (STT45), 348-358. October 7-9, 2019. Mae Fah Luang University, Chiang Rai, Thailand.

  • Suppharatthanya, P., Chaneam, S., Limpachayaporn, P., Jitnapa S. (2019). “Kinetics and Isotherm Study of the Adsorption of Brazilien from Sappanwood on Montmorillonite.” วารสารวิทยาศาสตร์และเทคโนโลยี, (27): 989-1001. (TCI-1)

  • Riam-Amatakun, W., Limpachayaporn, P., Rhea L. Pizon, J., Opanasopit, P., Nuntharatanapong, N. (2019). “Anti-Melanogenic Activity of p-Chlorophenyl Benzyl Ether inα-MSH-Induced Mouse Melanoma B16F10 Cells.” Key Engineering Materials, 2019 (819): 118-123. (Conference paper, Scopus)

  • Suttisintong, K., Palakhachane, S., Athipornchai, A., Pimtomg, W., Limpachayaporn, P. (2018). “Synthesis and evaluation of anti-tyrosinase activity of phenyl benzyl ether derivatives: Effects of functional groups and their positions.” Science, Engineering and Health Studies, 12(2): 111-123.

  • Klinpetch, W., Petdum, A., Thavornpradit, S., Panchan, W., Sooksimuang, T., Sirirak, J., Suvokhiaw, S., Limpachayaporn, P., Wanichacheva, N. (2018). “Fluorometric and colorimetric Hg2+ -sensor via FRET system of pentahelicene donor and rhodamine B acceptors.” Proceedings of the 2018 Chemistry Research Symposium (ChRS2018), 5-10. May 26-27, 2018. Chemistry Division, Faculty of Liberal Arts and Science, Kasetsart University Kamphaeng Saen Campus, Nakhon Pathom, Thailand.

  • Limpachayaporn, P., Schäfers, M., Haufe, G. (2015). “Isatin sulfonamides: Potent caspases-3 and -7 inhibitors and promising PET and SPECT radiotracers for apoptosis imaging.” Future Medicinal Chemistry, 7(9): 1173-1196.

  • Limpachayaporn, P., Wagner, S., Kopka, K., Schober, O., Schäfers, M., Haufe, G. (2014). “Synthesis of 7-halogenated isatin sulfonamides: Nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.” Journal of Medicinal Chemistry, 57(22): 9383-9395.

  • Limpachayaporn, P., Schäfers, M., Schober, O., Kopka, K., Haufe, G. (2013). “Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.” Bioorganic and Medicinal Chemistry, 21(7): 2025-2036.

  • Limpachayaporn, P., Riemann, B., Kopka, K., Schober, O., Schäfers, M., Haufe, G. (2013). “Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.” European Journal of Medicinal Chemistry, 64: 562-578.

  • Limpachayaporn, P., Wagner, S., Kopka, K., Hermann, S., Schäfers, M., Haufe, G. (2013). “Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.” Journal of Medicinal Chemistry, 56(11): 4509-4520.