Asst. Prof. Dr. Thanapon Charoenwongpaiboon


Room: 4210/6  Science Building 4

Tel.: 034-109686 ext. 207304

Website: -


Ph.D. (Biochemistry and Molecular Biology) Chulalongkorn University, Thailand

B.Sc. (Chemistry) Silpakorn University, Thailand

Research Interest:

  • Enzyme engineering and immobilization
  • Carbohydrate structure and synthesis
  • Carbohydrate-modifying enzyme


  • Charoenwongpaiboon, T., Wangpaiboon, K., Septham, P., Jiamvoraphong, N., Issaragrisil, S., Pichyangkura, R., Lorthongpanich, C. (2022). “Production and bioactivities of nanoparticulated and ultrasonic-degraded levan generated by Erwinia tasmaniensis levansucrase in human osteosarcoma cells.” International Journal of Biological Macromolecules, 221: 1121-1129.

  • Charoenwongpaiboon, T., Oo, A., Nasoontorn, S., Rungrotmongkol, T., Kanokmedhakul, S., Mahalapbutr, P. (2022). “Aurisin A complexed with 2,6-di-O-methyl-β-cyclodextrin enhances aqueous solubility, thermal stability, and antiproliferative activity against lung cancer cells.” International Journal of Molecular Sciences, 23(17): 9776

  • Charoenwongpaiboon, T., Wangpaiboon, K., Klaewkla, M., Kuttiyawong, K., Field, R.A., Pichyangkura, R. (2022). “Levan-type fructooligosaccharides synthesis by novel levansucrase-inulosucrase fusion enzyme.” Biochemical engineering journal, 185: 108524.

  • Lorthongpanich, N., Mahalapbutr, P., Rungrotmongkol, T., Charoenwongpaiboon, T., Prousoontorn, M. H. (2022). “Fisetin glycosides synthesized by cyclodextrin glycosyltransferase from Paenibacillus sp. RB01: Characterization, molecular docking, and antioxidant activity.” PeerJ, 10: e13467.

  • Mahalapbutr, P., Klaewkla, M., Charoenwongpaiboon, T. (2022). “Unraveling the effect of A143T, P205T and D244N mutations in a-galactosidase A on its catalytic activity and susceptibility to globotriaosylceramide and iminosugar 1-deoxygalactonojirimycin chaperone.” Journal of Molecular Liquids, 353: 118790.

  • Wangpaiboon, K., Klaewkla, M., Charoenwongpaiboon, T., Vongkusolkit, N., Panpetch, P., Kuttiyawong, K., Visessanguan, W., Pichyangkura, R. (2022). “Synergistic enzyme cocktail between levansucrase and inulosucrase for superb levan-type fructooligosaccharide synthesis.” Enzyme and microbial technology, 154: 109960.

  • Leerawatthanakun, S., Charoenwongpaiboon, T., Klaewkla, M., Chunsrivirot, S., Sirirak, J., Sriwitool, T., Wangpaiboon, K., Pichyangkura, R. (2022). “High surfactant-tolerant β-mannanase isolated from Dynastes hercules larvae excrement, and identification of its hotspot using site-directed mutagenesis and molecular dynamic simulations.” Enzyme and microbial technology, 154: 109956.

  • Charoenwongpaiboon., Laowtammathron, C., Lorthongpanich, C. (2021). “Therapeutic opportunities for cancers presented by natural and synthetic compounds targeting the Hippo signaling pathway” ScienceAsia, Accepted. (ISI, SCOPUS)

  • Charoenwongpaiboon, T., Wangpaiboon, K., Pichyangkura, R., Nepogodiev, S. A., Wonganan, P., Mahalapbutr, P., Field, R. A. (2021). “Characterization of a nanoparticulate exopolysaccharide from Leuconostoc holzapfelii KM01 and its potential application in drug encapsulation.” International Journal of Biological Macromolecules, 187: 690-698. (ISI/SCOPUS)

  • Charoenwongpaiboon, T., Wangpaiboon, K., Pichyangkura, R. (2021). “Cross-linked levansucrase aggregates for fructooligosaccharide synthesis in fruit juices.” LWT, 150: 112080. (ISI, SCOPUS)

  • Lorthongpanich, C., Charoenwongpaiboon, T., Supakun, P., Klaewkla, M., Kheolamai, P., Issaragrisil, S. (2021). “Fisetin inhibits osteogenic differentiation of mesenchymal stem cells via the inhibition of YAP.” Antioxidants, 10(6): 879. (ISI, SCOPUS)

  • Klaewkla, M., Charoenwongpaiboon, T., Mahalapbutr, P. (2021). “Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists.” Journal of Molecular Liquids, 335: 116537. (ISI, SCOPUS)

  • Mahalapbutr, P., Charoenwongpaiboon, T., Phongern, C., Kongtaworn, N., Hannongbua, S., Rungrotmongkol, T. (2021). “Molecular encapsulation of a key odor-active 2-acetyl-1-pyrroline in aromatic rice with β-cyclodextrin derivatives.” Journal of Molecular Liquids, 337: 116394. (ISI, SCOPUS)

  • Wangpaiboon, K., Sitthiyotha, T., Chunsrivirot, S., Charoenwongpaiboon, T., Pichyangkura, R. (2021). “Unravelling Regioselectivity of Leuconostoc citreum ABK-1 Alternansucrase by Acceptor Site Engineering.” International Journal of Molecular Sciences, 22(6): 3229. (ISI, SCOPUS)

  • Phengnoi, P., Charoenwongpaiboon, T., Wangpaiboon, K., Klaewkla, M., Nakapong, S., Visessanguan, W., Ito, K., Pichyangkura, R., Kuttiyawong, K. (2020). “Levansucrase from Bacillus amyloliquefaciens KK9 and its Y237 Svariant producing the high bioactive levan-type fructooligosaccharides.” Biomolecules, 10(5): 692.

  • Klaewkla, M., Pichayangkura, R., Charoenwongpaiboon, T., Wangpaiboon, K., Chunsrivirot, S. (2020). “Computational design of oligosaccharide producing levansucrase from Bacillus licheniformis RN-01 to improve its thermostability for production of levan-type fructooligosaccharides from sucrose.” International Journal of Biological Macromolecules, 160: 252-263.

  • Charoenwongpaiboon, T., Punnatin, P., Klaewkla, M., Pramoj Na Ayutthaya, P., Wangpaiboon, K., Chunsrivirot, S., Field, R.A., Pichyangkura, R. (2020). “Conserved Calcium-Binding Residues at the Ca-I Site Involved in Fructooligosaccharide Synthesis by Lactobacillus reuteri 121 Inulosucrase.” ACS omega, 5(43): 28001–28011.

  • Wangpaiboon, K., Waiyaseesang, N., Panpetch, P., Charoenwongpaiboon, T., Nepogodiev, S. A., Ekgasit, S., Field, R. A., Pichayangkura, R. (2020). “Characterisation of insoluble α-1, 3-/α-1, 6 mixed linkage glucan produced in addition to soluble α-1,6-linked dextran by glucansucrase (DEX-N) from Leuconostoc citreum ABK-1.” International Journal of Biological Macromolecules, 152: 473-482 (ISI/SCOPUS)

  • Nopvichai, C., Pongkorpsakol, P., Wongkrasant, P., Wangpaiboon, K., Charoenwongpaiboon, T., Ito, K., Muanprasat, C., Pichyangkura, R. (2019). “Galactomannan pentasaccharide produced from copra meal enhances tight junction integration of epithelial tissue through activation of AMPK.” Biomedicines, 7(4): 81. (ISI/SCOPUS)

  • Mahalapbutr, P., Wonganan, P., Charoenwongpaiboon,, Prousoontorn, M. H., Chavasiri, W., Rungrotmongkol, T. (2019). “Enhanced solubility and anticancer potential of mansonone G by β-cyclodextrin-based host-guest complexation: A computational and experimental study.” Biomolecules, 9(10): 545. (ISI/SCOPUS)

  • Kanjanatanin, P., Pichyangkura, R., Sitthiyotha, T., Charoenwongpaiboon,, Wangpaiboon, K., Chunsrivirot, S. (2019). “Computational design of Bacillus licheniformis RN-01 levansucrase for control of the chain length of levan-type fructooligosaccharides.” International Journal of Biological Macromolecules, 140: 1239-1248. (ISI/SCOPUS)

  • Charoenwongpaiboon,, Pichyangkura, R., Field, R. A., Prousoontorn, M. H. (2019). “Preparation of cross-linked enzyme aggregates (CLEAs) of an inulosucrase mutant for the enzymatic synthesis of inulin-type fructooligosaccharides.” Catalysts, 9(8): 641. (ISI/SCOPUS)

  • Charoenwongpaiboon, , Wangpaiboon, K., Panpetch, P., Field, R. A., Barclay, J. E., Pichyangkura, R., Kuttiyawong, K. (2019). “Temperature-dependent inulin nanoparticles synthesized by Lactobacillus reuteri 121 inulosucrase and complex formation with flavonoids.” Carbohydrate Polymers, 223: 115044. (ISI/SCOPUS)

  • Nopvichai, C., Charoenwongpaiboon,, Luengluepunya, N., Ito, K., Muanprasat, C., Pichyangkura, R. (2019). “Production and purification of mannan oligosaccharide with epithelial tight junction enhancing activity.” PeerJ, 7: e7206. (ISI/SCOPUS)

  • Wangpaiboon, K., Pitakchatwong, C., Panpetch, P., Charoenwongpaiboon,, Field, R. A., Pichyangkura, R. (2019). “Modified properties of alternan polymers arising from deletion of SH3-like motifs in Leuconostoc citreum ABK-1 alternansucrase.” Carbohydrate Polymers, 220: 103-109. (ISI/SCOPUS)

  • Charoenwongpaiboon,, Klaewkla, M., Chunsrivirot, S., Wangpaiboon, K., Pichyangkura, R., Field, R. A., Prousoontorn, M. H. (2019). “Rational re-design of Lactobacillus reuteri 121 inulosucrase for product chain length control.” RSC Advances, 9(26): 14957-14965. (ISI/SCOPUS)

  • Charonwongpaiboon,, Supraditaporn, K., Klaimon, P., Wangpaiboon, K., Pichyangkura, R., Issaragrisil, S., Lorthongpanich, C. (2019). “Effect of alternan versus chitosan on the biological properties of human mesenchymal stem cells.” RSC Advances, 9(8): 4370-4379. (ISI/SCOPUS)

  • Charoenwongpaiboon,, Sitthiyotha, T., Ayutthaya, P. P. N., Wangpaiboon, K., Chunsrivirot, S., Prousoontorn, M. H., Pichyangkura, R. (2019). “Modulation of fructooligosaccharides chain length and insight into the product binding motif of Lactobacillus reuteri 121 Inulosucrase.” Carbohydrate Polymers, 209: 111-121. (ISI/SCOPUS)

  • Wangpaiboon, K., Padungros, P., Nakapong, S., Charoenwongpaiboon,, Rejzek, M., Field, R. A., Pichyangkura, R. (2018). “An α-1, 6-and α-1, 3-linked glucan produced by Leuconostoc citreum ABK-1 alternansucrase with nanoparticle and film-forming properties” Scientific reports, 8(1): 8340. (ISI/SCOPUS)

  • Charoenwongpaiboon,, Wangpaiboon, K., Pichyangkura, R., Prousoontorn, M. H. (2018). “Highly porous core–shell chitosan beads with superb immobilization efficiency for Lactobacillus reuteri 121 inulosucrase and production of inulin-type fructooligosaccharides.” RSC Advances, 8(30): 17008-17016. (ISI/SCOPUS)